2025
51
Jain G., Eddy MT. “The influence of lipids and biological membranes on the conformational equilibria of GPCRs: Insights from NMR spectroscopy” Curr. Opin. Struct. Biol. (2025) 94, 103103.
50
Ray A.P., Jin B., Eddy MT. “The Conformational equilibria of a human GPCR compared between lipid vesicles and aqueous solutions by integrative 19F-NMR“. J. Am. Chem. Soc. (2025) 147, 17612-17625.
49
Petracco E, Ferré G, Kabelka I, Ballante F, Carlsson J, Mulry E, Ray AP, Collins J, Allais F, Eddy MT. “Development of an in situ GPCR fragment molecule screening approach with HRMAS NMR.” ACS Chem. Biol. (2025) 20, 401-411
48
Conflitti P, Lyman E, Sansom MSP, Hildebrand PW, Gutiérrez-de-Terán H, Carloni P, Ansell TB, Yuan S, Barth P, Robinson AS, Tate CG, Gloriam D, Grzesiek S, Eddy MT, Prosser S, Limongelli V. “Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery.” Nature Rev. Drug Disc. (2025) 24, 251-275.
47
Silva L.O., Wijesekara, A.V., Eddy M.T. “NMR Spectroscopy Reveals Insights into Mechanisms of GPCR Signaling.” Trends in Biochem. Sci. (2025) 1, 84-85.
2024
46
Anazia K, Koenekoop L, Ferré G, Petracco E, Gutiérrez-de-Teran H, Eddy MT. “Interaction Networks within Disease-Associated GaS Variants Characterized by an Integrative Biophysical Approach.” J. Biol. Chem. (2024) 300, 107497.
45
Thakur N, Ray AP, Lyman E, Gao ZG, Jacobson KA, Eddy MT. “Membrane Mimetic-Dependence of GPCR Energy Landscapes.” Structure (2024) 32, 523-535.
2023
44
Wei S, Thakur N, Pour NG, Tiruvadi-Krishnan S, Ray AP, Thakur N, Eddy MT*, Lamichhane R*. “Single-Molecule Visualization of Human A2A Adenosine Receptor Activation by a G Protein and Constitutively Activating Mutations,” Comm. Biol. (2023) 6, 1218. *co-corresponding authors
43
Jin B, Thakur N, Wijesekara AV, Eddy MT. “Illuminating GPCR Signaling Mechanisms by NMR Spectroscopy with Stable-Isotope Labeled Receptors.” Curr. Opin. Pharm. (2023) 72, 102364.
42
Ray AP, Thakur N, Pour NG, Eddy MT. “Dual Mechanisms of Cholesterol-GPCR Interactions that Depend on Membrane Phospholipid Composition.” Structure (2023) 31, 836-847.
41
Pritzlaff A, Ferré G, Dargassies E, Williams CO, Gonzalez DD, Eddy MT. “Conserved Protein–Polymer Interactions across Structurally Diverse Polymers Underlie Alterations to Protein Thermal Unfolding.” ACS Central Science (2023) 9, 685-695.
40
Thakur N, Ray AP, Sharp L, Jin B, Duong A, Pour NG, Obeng S, Wijesekara AV, Gao Z-G, McCurdy CR, Jacobson KA, Lyman E, Eddy MT. “Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition.” Nature Comm. (2023) 14, 794.
2022
39
Ferré G, Anazia K, Silva LO, Thakur N, Ray AP, Eddy MT. “Global Insights into the Fine-Tuning of Human A2AAR Conformational Dynamics in a Ternary Complex with an Engineered G Protein Viewed by NMR.” Cell Reports (2022) 41, 111844.
38
Pritzlaff A, Ferré G, Mulry E, Lin L, Gopal Pour N, Savin DA, Harris M, Eddy MT. “Atomic‐Scale View of Protein–PEG Interactions that Redirect the Thermal Unfolding Pathway of PEGylated Human Galectin‐3.” Angewandte Chemie International Edition (2022) 61, e202203784.
37
Thakur N, Wei S, Ray AP, Lamichhane R, Eddy MT. “Production of Human A2AAR in Lipid Nanodiscs for 19F-NMR and Single-Molecule Fluorescence Spectroscopy,” STAR Protocols (2022) 3, 101535.
36
You X, Thakur N, Ray AP, Eddy MT*, Baiz CR*. “A Comparative Study of Interfacial Environments in Lipid Nanodiscs and Vesicles,” Biophysical Reports (2022) 2, 100066. *co-corresponding authors
2021
35
Wei S, Thakur N, Arka P. Ray, Jin B, Obeng S, McCurdy CR, McMahon LR, Gutiérrez-de-Terán H, Eddy MT*, Lamichhane R*. “Slow Conformational Dynamics of the Human A2A Adenosine Receptor are Temporally Ordered,” Structure (2021) 30, 329-337. *co-corresponding authors
34
Mulry EK, Ray AP, Eddy MT. “Production of a Human Histamine Receptor for NMR Spectroscopy in Aqueous Solutions,” Biomolecules (2021) 11, 632-646.
33
Silvers RS, Eddy MT. “NMR Spectroscopic Studies of Ion Channels in Lipid Bilayers: Sample Preparation Strategies Exemplified by the Voltage Dependent Anion Channel.” Methods Mol Bio (2021) 2302, 201-217.
32
Eddy MT*, Martin BT, Wüthrich K. “A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch,” Structure (2021) 29, 170-176. *corresponding author
2020
31
Jacobson KA, Gao ZG, Matricon P, Eddy MT, Carlsson J. “Adenosine A2A Receptor Antagonists: From Caffeine to Selective Non-xanthines.” British J. Pharm. (2020) 172, 1-16.
30
Ferré G, Eddy MT. “Structural Biology of GPCR Drugs and Endogenous Ligands – Insights from NMR Spectroscopy,” Methods (2020) 180, 79-88.
2019
29
Eddy MT, Yu T-Y, Wagner G, Griffin RG. “Structural Characterization of the Human Membrane Protein VDAC2 in Lipid Bilayers by Solid State NMR,” J. Bio. NMR (2019) 73, 451-460.
28
Shimada I, Ueda T, Kofuku Y, Eddy MT, Wüthrich K. “GPCR Drug Discovery: Integrating Solution NMR Data with Crystal and Cryo-EM Structures,” Nature Rev. Drug Disc. (2019) 19, 59-82.
2018
27
Sušac L, Eddy MT, Didenko T, Stevens RC, Wüthrich K. “A2A adenosine receptor functional states characterized by 19F-NMR,” Proc. Natl. Acad. Sci. (2018) 115, 12733-12738.
26
Eddy MT, Gao Z-G, Mannes P, Patel N, Jacobson KA, Katritch V, Stevens RC, Wüthrich K. “Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor,” J. Am. Chem. Soc. (2018) 140, 8228-8235.
25
Eddy MT, Lee M-Y, Gao Z-G, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wüthrich K. “Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor,” Cell (2018) 172, 68-80.
24
White K*, Eddy MT*, Gao Z-G, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC. “Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling,” Structure (2018) 26, 1-11. *Co-first authors
2016
23
Eddy MT, Didenko T, Stevens RC, Wüthrich K. “β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop,” Structure (2016) 24, 2190-2197.
